Thursday, February 21, 2019

Autonomic Nervous System, again

This is a topic that I've mostly blogged about before- see here.

Discuss autonomic control
Describe the role of the ANS in vegetative functions
Describe the neurotransmitter & synaptic physiology of the ANS
Discuss the function of the adrenal medulla in the ‘Alarm’ or ‘Stress’ response 
Name some drugs that can be used to manipulate the function of the ANS

Many drugs can manipulate the function of the ANS by either activating or blocking receptors involved in the ANS. Some examples (note some drugs might be able to block multiple receptors):





Activating (Agonist) Blocking (Antagonist)
α1-adrenoceptor Phenylephrine Phentolamine
α2-adrenoceptor Clonidine Phentolamine
β1-adrenoceptor Dobutamine Propranolol
β2-adrenoceptor Salbutamol Propranolol
Nicotinic receptor Nicotine Hexamethonium
Muscarinic receptor Muscarine Atropine

Define NANC neurotransmitters

NANC neurotransmitters are "non-adrenergic, non-cholinergic." Examples of NANC neurotransmitters include ATP, nitric oxide, VIP (vasoactive intestinal polypeptide), and so on.

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